2,879 research outputs found
Unified force law for granular impact cratering
Experiments on the low-speed impact of solid objects into granular media have
been used both to mimic geophysical events and to probe the unusual nature of
the granular state of matter. Observations have been interpreted in terms of
conflicting stopping forces: product of powers of projectile depth and speed;
linear in speed; constant, proportional to the initial impact speed; and
proportional to depth. This is reminiscent of high-speed ballistics impact in
the 19th and 20th centuries, when a plethora of empirical rules were proposed.
To make progress, we developed a means to measure projectile dynamics with 100
nm and 20 us precision. For a 1-inch diameter steel sphere dropped from a wide
range of heights into non-cohesive glass beads, we reproduce prior observations
either as reasonable approximations or as limiting behaviours. Furthermore, we
demonstrate that the interaction between projectile and medium can be
decomposed into the sum of velocity-dependent inertial drag plus
depth-dependent friction. Thus we achieve a unified description of low-speed
impact phenomena and show that the complex response of granular materials to
impact, while fundamentally different from that of liquids and solids, can be
simply understood
Hierarchical Reinforcement Learning under Mixed Observability
The framework of mixed observable Markov decision processes (MOMDP) models
many robotic domains in which some state variables are fully observable while
others are not. In this work, we identify a significant subclass of MOMDPs
defined by how actions influence the fully observable components of the state
and how those, in turn, influence the partially observable components and the
rewards. This unique property allows for a two-level hierarchical approach we
call HIerarchical Reinforcement Learning under Mixed Observability (HILMO),
which restricts partial observability to the top level while the bottom level
remains fully observable, enabling higher learning efficiency. The top level
produces desired goals to be reached by the bottom level until the task is
solved. We further develop theoretical guarantees to show that our approach can
achieve optimal and quasi-optimal behavior under mild assumptions. Empirical
results on long-horizon continuous control tasks demonstrate the efficacy and
efficiency of our approach in terms of improved success rate, sample
efficiency, and wall-clock training time. We also deploy policies learned in
simulation on a real robot.Comment: Accepted at the 15th International Workshop on the Algorithmic
Foundations of Robotics (WAFR) 2022, University of Maryland, College Park.
The first two authors contributed equall
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Genetically and metabolically corrected pluripotent stem cells from patients with mtDNA disease
Results of the DAMA experiment at LNGS
DAMA is searching for rare processes by developing and using several kinds of radiopure scintillators: in particular, NaI(Tl), liquid Xenon and CaF2(Eu). Here more recent results are summarized with particular attention to the investigation of the WIMP annual modulation signature
Breakdown of Fermi-liquid theory in a cuprate superconductor
The behaviour of electrons in solids is remarkably well described by Landau's
Fermi-liquid theory, which says that even though electrons in a metal interact
they can still be treated as well-defined fermions, called ``quasiparticles''.
At low temperature, the ability of quasiparticles to transport heat is strictly
given by their ability to transport charge, via a universal relation known as
the Wiedemann-Franz law, which no material in nature has been known to violate.
High-temperature superconductors have long been thought to fall outside the
realm of Fermi-liquid theory, as suggested by several anomalous properties, but
this has yet to be shown conclusively. Here we report on the first experimental
test of the Wiedemann-Franz law in a cuprate superconductor,
(Pr,Ce)CuO. Our study reveals a clear departure from the universal law
and provides compelling evidence for the breakdown of Fermi-liquid theory in
high-temperature superconductors.Comment: 7 pages, 3 figure
Study protocol: improving cognition in people with progressive multiple sclerosis: a multi-arm, randomized, blinded, sham-controlled trial of cognitive rehabilitation and aerobic exercise (COGEx)
Background: Cognitive dysfunction affects up to 70% of people with progressive MS (PMS). It can exert a deleterious effect on activities of daily living, employment and relationships. Preliminary evidence suggests that performance can improve with cognitive rehabilitation (CR) and aerobic exercise (EX), but existing data are predominantly from people with relapsing-remitting MS without cognitive impairment. There is therefore a need to investigate whether this is also the case in people with progressive forms of the disease who have objectively identified cognitive impairment. It is hypothesized that CR and EX are effective treatments for people with PMS who have cognitive impairment, in particular processing speed (PS) deficits, and that a combination of these two treatments is more effective than each individual treatment given alone. We further hypothesize that improvements in PS will be associated with modifications of functional and/or structural plasticity within specific brain networks/regions involved in PS measured with advanced MRI techniques. Methods: This study is a multisite, randomized, double-blinded, sham controlled clinical trial of CR and aerobic exercise. Three hundred and sixty subjects from 11 sites will be randomly assigned into one of four groups: CR plus aerobic exercise; CR plus sham exercise; CR sham plus aerobic exercise and CR sham plus sham exercise. Subjects will participate in the assigned treatments for 12 weeks, twice a week. All subjects will have a cognitive and physical assessment at baseline, 12 weeks and 24 weeks. In an embedded sub-study, approximately 30% of subjects will undergo structural and functional MRI to investigate the neural mechanisms underlying the behavioral response. The primary outcome is the Symbol Digit Modalities Test (SDMT) measuring PS. Secondary outcome measures include: indices of verbal and non-verbal memory, depression, walking speed and a dual cognitive-motor task and MRI. Discussion: The study is being undertaken in 6 countries (11 centres) in multiple languages (English, Italian, Danish, Dutch); with testing material validated and standardized in these languages. The rationale for this approach is to obtain a robustly powered sample size and to demonstrate that these two interventions can be given effectively in multiple countries and in different languages. Trial registration: The trial was registered on September 20th 2018 at www.clinicaltrials.gov having identifier NCT03679468. Registration was performed before recruitment was initiated
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